ARID1A |
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![](http://178.128.105.246/content-http-upload.wikimedia.org/wikipedia/commons/thumb/2/2e/Protein_ARID1A_PDB_1ryu.png/250px-Protein_ARID1A_PDB_1ryu.png) |
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Dynodwyr |
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Cyfenwau | ARID1A, B120, BAF250, BAF250a, BM029, C1orf4, ELD, MRD14, OSA1, P270, SMARCF1, hELD, hOSA1, CSS2, AT-rich interaction domain 1A |
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Dynodwyr allanol | OMIM: 603024 HomoloGene: 21216 GeneCards: ARID1A |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • DNA binding • GO:0001105 transcription coactivator activity • GO:0001948, GO:0016582 protein binding • nuclear receptor binding • nucleosome binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
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Cydrannau o'r gell | • nBAF complex • SWI/SNF complex • nucleoplasm • npBAF complex • cnewyllyn cell • SWI/SNF superfamily-type complex • brahma complex
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Prosesau biolegol | • androgen receptor signaling pathway • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cardiac muscle cell differentiation • optic cup formation involved in camera-type eye development • placenta blood vessel development • GO:1901227 negative regulation of transcription by RNA polymerase II • toxin transport • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • transcription, DNA-templated • nervous system development • cardiac chamber development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • neural tube closure • nucleosome disassembly • forebrain development • intracellular estrogen receptor signaling pathway • glucocorticoid receptor signaling pathway • formation of primary germ layer • gastrulation • embryo implantation • stem cell population maintenance
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn ARID1A yw ARID1A a elwir hefyd yn AT-rich interaction domain 1A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARID1A.
- ELD
- B120
- CSS2
- OSA1
- P270
- hELD
- BM029
- MRD14
- hOSA1
- BAF250
- C1orf4
- BAF250a
- SMARCF1
- "[Expression and clinical significance of ARID1A in gastric cancer and paired adjacent noncancerous tissues]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017. PMID 28031120.
- "Low expression of ARID1A correlates with poor prognosis in intrahepatic cholangiocarcinoma. ". World J Gastroenterol. 2016. PMID 27433094.
- "ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. ". Biochem Biophys Res Commun. 2017. PMID 28716731.
- "Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells. ". Cancer Lett. 2017. PMID 28483516.
- "Morphological Features and Prognostic Significance of ARID1A-Deficient Esophageal Adenocarcinomas.". Arch Pathol Lab Med. 2017. PMID 28440661.