CUL4B |
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Dynodwyr |
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Cyfenwau | CUL4B, CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2, cullin 4B |
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Dynodwyr allanol | OMIM: 300304 HomoloGene: 2660 GeneCards: CUL4B |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • damaged DNA binding • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding
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Cydrannau o'r gell | • cullin-RING ubiquitin ligase complex • nucleoplasm • extracellular exosome • cnewyllyn cell • cytosol • Cul4B-RING E3 ubiquitin ligase complex • Cul4-RING E3 ubiquitin ligase complex • SCF ubiquitin ligase complex
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Prosesau biolegol | • GO:1903364 positive regulation of protein catabolic process • nucleotide-excision repair, DNA damage recognition • ubiquitin-dependent protein catabolic process • histone H2A monoubiquitination • cellular response to DNA damage stimulus • positive regulation of G1/S transition of mitotic cell cycle • global genome nucleotide-excision repair • cell cycle • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • neuron projection development • UV-damage excision repair • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 3'-to lesion • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA duplex unwinding • GO:0100026 DNA repair • nucleotide-excision repair, preincision complex stabilization • post-translational protein modification • proteasomal protein catabolic process • protein ubiquitination • G1/S transition of mitotic cell cycle • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn CUL4B yw CUL4B a elwir hefyd yn Cullin 4B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq24.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CUL4B.
- SFM2
- MRXSC
- CUL-4B
- MRXHF2
- MRXS15
- "CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells. ". Oncol Rep. 2014. PMID 25189186.
- "Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability. ". Am J Med Genet A. 2014. PMID 24898194.
- "Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells. ". Proteomics. 2017. PMID 28225217.
- "Knockdown of CUL4B Suppresses the Proliferation and Invasion in Non-Small Cell Lung Cancer Cells. ". Oncol Res. 2016. PMID 27656838.
- "Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway.". Int J Clin Exp Pathol. 2015. PMID 26617747.