DOTAM
Appearance
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Names | |
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IUPAC name
2-[4,7,10-tris(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide
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Other names
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C16H32N8O4 | |
Molar mass | 400.484 g·mol−1 |
Appearance | White powder |
Soluble (hygroscopic) | |
Hazards | |
GHS labelling: | |
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Warning | |
H315, H319, H335 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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DOTAM (also known as TCMC) is an organic compound used as a chelator much like its carboxylic acid analog DOTA. A derivative with a reactive linking group of para-isothiocyanatobenzyl attached to the cyclen ring is also of interest as a bifunctional chelator (BFC).[1][2]
![](http://178.128.105.246/content-http-upload.wikimedia.org/wikipedia/commons/thumb/f/fa/P-SCN-Bn-TCMC.png/220px-P-SCN-Bn-TCMC.png)
References
[edit]- ^ Brennecke, Benjamin; Wang, Qinghua; Haap, Wolfgang; Grether, Uwe; Hu, Hai-Yu; Nazaré, Marc (2021-04-21). "DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells". Bioconjugate Chemistry. 32 (4): 702–712. doi:10.1021/acs.bioconjchem.0c00699. ISSN 1043-1802. PMID 33691062. S2CID 232192471.
- ^ Stenberg, Vilde Yuli; Larsen, Roy Hartvig; Ma, Li-Wei; Peng, Qian; Juzenas, Petras; Bruland, Øyvind Sverre; Juzeniene, Asta (January 2021). "Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer". International Journal of Molecular Sciences. 22 (9): 4815. doi:10.3390/ijms22094815. PMC 8124365. PMID 34062920.