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Ophiolysin

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Ophiolysin
Identifiers
EC no.3.4.24.51
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Ophiolysin (EC 3.4.24.51, Ophiophagus metalloendopeptidase) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Cleavage of Asn3-Gln, Gln4-His, His10-Leu, Ala14-Leu, and Tyr16-Leu in insulin B chain

This endopeptidase is present in the venom of the king cobra (Ophiophagus hannah)

References

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  1. ^ Yamakawa Y, Omori-Satoh T (1988). "A protease in the venom of king cobra (Ophiophagus hannah): purification, characterization and substrate specificity on oxidized insulin B-chain". Toxicon. 26 (12): 1145–55. doi:10.1016/0041-0101(88)90299-1. PMID 3070833.
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