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RNF123

From Wikipedia, the free encyclopedia
RNF123
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF123, KPC1, FP1477, ring finger protein 123
External IDsOMIM: 614472; MGI: 2148796; HomoloGene: 11112; GeneCards: RNF123; OMA:RNF123 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022064

NM_032543
NM_001311152

RefSeq (protein)

NP_071347

NP_001298081
NP_115932

Location (UCSC)Chr 3: 49.69 – 49.72 MbChr 9: 107.93 – 107.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.[5]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.[5] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164068Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041528Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RNF123 ring finger protein 123".

Further reading

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