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Sorbose reductase

From Wikipedia, the free encyclopedia
sorbose reductase
Identifiers
EC no.1.1.1.289
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
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NCBIproteins

In enzymology, a sorbose reductase (EC 1.1.1.289) is an enzyme that catalyzes the chemical reaction

D-glucitol + NADP+ L-sorbose + NADPH + H+

Thus, the two substrates of this enzyme are D-glucitol and NADP+, whereas its 3 products are L-sorbose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glucitol:NADP+ oxidoreductase. This enzyme is also called Sou1p.

References

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  • Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E (2005). "Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization". Yeast. 22 (12): 957–69. doi:10.1002/yea.1282. PMID 16134116.
  • Rustchenko E (2005). "Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization". Yeast. 22 (14): 1171. doi:10.1002/yea.1310.
  • Sugisawa T, Hoshino T, Fujiwara A (1991). "Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1". Agric. Biol. Chem. 55 (8): 2043–2049. doi:10.1271/bbb1961.55.2043.
  • Shinjoh M, Tazoe M, Hoshino T (2002). "NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291". J. Bacteriol. 184 (3): 861–3. doi:10.1128/JB.184.3.861-863.2002. PMC 139518. PMID 11790761.