O-806
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(IUPAC) ime | |||
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(6aR)-3-(6-bromoheks-2-inil)-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol | |||
Klinički podaci | |||
Identifikatori | |||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 10549140 | ||
ChemSpider[3] | 26001356 | ||
Hemijski podaci | |||
Formula | C22H27BrO2 | ||
Mol. masa | 403,352 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
O-806 je lek koji je kanabinoidni derivat sa primenom u naučnim istraživanjima. On je mešoviti agonist/antagonist kanabinoidnog receptora CB1. Drugim rečima on deluje kao antagonist kad se dozira zajedno sa potentnijim CB1 agonistom, dok je slab parcijalni agonist u odsustvu drugog agonist.[4][5]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Griffin, G.; Wray, E.; Rorrer, W.; Crocker, P.; Ryan, W.; Saha, B.; Razdan, R.; Martin, B. i dr.. (1999). „An investigation into the structural determinants of cannabinoid receptor ligand efficacy”. British Journal of Pharmacology 126 (7): 1575–1584. DOI:10.1038/sj.bjp.0702469. PMC 1565939. PMID 10323589.
- ↑ Griffin, G.; Wray, E.; Martin, B.; Abood, M. (1999). „Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum”. British Journal of Pharmacology 128 (3): 684–688. DOI:10.1038/sj.bjp.0702806. PMC 1571656. PMID 10516649.