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P4HTM

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P4HTM
Identifiers
AliasesP4HTM, EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4, prolyl 4-hydroxylase, transmembrane, HIDEA
External IDsOMIM: 614584; MGI: 1921693; HomoloGene: 41765; GeneCards: P4HTM; OMA:P4HTM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017732
NM_177938
NM_177939

NM_028944
NM_001357465

RefSeq (protein)

NP_808807
NP_808808

NP_083220
NP_001344394

Location (UCSC)Chr 3: 48.99 – 49.01 MbChr 9: 108.46 – 108.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene. [5]

Function

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The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178467Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006675Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Prolyl 4-hydroxylase, transmembrane". Retrieved 2017-10-03.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.