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NUDT3

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NUDT3
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2FVV, 2Q9P

Identifikatori
AliasiNUDT3
Vanjski ID-jeviOMIM: 609228 MGI: 1928484 HomoloGene: 31400 GeneCards: NUDT3
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za NUDT3
Genomska lokacija za NUDT3
Bend6p21.31Početak34,279,679 bp[1]
Kraj34,392,669 bp[1]
Lokacija gena (miš)
Hromosom 17 (miš)
Hrom.Hromosom 17 (miš)[2]
Hromosom 17 (miš)
Genomska lokacija za NUDT3
Genomska lokacija za NUDT3
Bend17|17 A3.3Početak27,798,356 bp[2]
Kraj27,842,469 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
inositol diphosphate tetrakisphosphate diphosphatase activity
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
hydrolase activity
diphosphoinositol-polyphosphate diphosphatase activity
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
vezivanje iona metala
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
magnesium ion binding
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
inositol diphosphate pentakisphosphate diphosphatase activity
inositol bisdiphosphate tetrakisphosphate diphosphatase activity
endopolyphosphatase activity
bis(5'-adenosyl)-hexaphosphatase activity
bis(5'-adenosyl)-pentaphosphatase activity
m7G(5')pppN diphosphatase activity
Ćelijska komponenta jedro
citoplazma
citosol
Biološki proces cell-cell signaling
diadenosine polyphosphate catabolic process
inositol phosphate metabolic process
diphosphoinositol polyphosphate catabolic process
diadenosine pentaphosphate catabolic process
diadenosine hexaphosphate catabolic process
adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
diphosphoinositol polyphosphate metabolic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_006703

NM_001291046
NM_019837

RefSeq (bjelančevina)

NP_006694

NP_001277975
NP_062811

Lokacija (UCSC)Chr 6: 34.28 – 34.39 MbChr 17: 27.8 – 27.84 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Difosfoinozitol-polifosfatna fosfohidrolaza 1 jest enzim koji je kod ljudi kodiran genom NUDT3.[5][6]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 172 aminokiseline, а molekulska težina 19.471 Da.[7].

1020304050
MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPG
GGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIV
TEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSAN
NGTPVVATTYSVSAQSSMSGIR

Funkcija

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NUDT3 pripada porodici proteina MutT, ili Nudix. Proteini Nudix djeluju kao homeostatske kontrolne tsčke u važnim fazama metaboličkih puteva nukleozid fosfata, štiteći od povišenih razina potencijalno opasnih međuprodukata, poput 8-okso-dGTP, koji podstiče transverzije AT-u-CG (Safrany et al., 1998, prema OMIMu)[6]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000272325 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024213 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB (Jan 1999). "A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase". EMBO J. 17 (22): 6599–607. doi:10.1093/emboj/17.22.6599. PMC 1171006. PMID 9822604.
  6. ^ a b "Entrez Gene: NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3".
  7. ^ "UniProt, O95989" (jezik: engleski). Pristupljeno 4. 10. 2021.

Dopunska literatura

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Vanjski linkovi

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