SX-3228
 | |
| Clinical data | |
|---|---|
| Other names | 5,6,7,8-tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)-6-(phenylmethyl)-1,6-naphthyridin-2(1H)-one |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C18H18N4O3 |
| Molar mass | 338.367 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
SX-3228 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.
SX-3228 is a subtype-selective GABAA positive allosteric modulator acting primarily at the α1 subtype. It thus has similar effects to other α1-selective drugs such as zolpidem and zaleplon in animal studies.[1][2] It only partly substitutes for ethanol, and is a strong sedative-hypnotic with only limited anxiolytic effects which appear only at doses that also produce significant sedation.[3][4]
References
- ^ Sanger DJ (August 1997). "The effects of new hypnotic drugs in rats trained to discriminate ethanol". Behavioural Pharmacology. 8 (4): 287–92. doi:10.1097/00008877-199708000-00002. PMID 9832988. S2CID 42758930.
- ^ Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ (September 1999). "Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands". Behavioural Pharmacology. 10 (5): 483–95. doi:10.1097/00008877-199909000-00007. PMID 10780255.
- ^ Griebel G, Perrault G, Sanger DJ (1998). "Limited anxiolytic-like effects of non-benzodiazepine hypnotics in rodents". Journal of Psychopharmacology. 12 (4): 356–65. doi:10.1177/026988119801200405. PMID 10065909. S2CID 269304.
- ^ Alvariño F, Monti JM, Jantos H, Monti D (August 1999). "Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat". Brazilian Journal of Medical and Biological Research. 32 (8): 1007–14. doi:10.1590/s0100-879x1999000800011. PMID 10454763.