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ACO1

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ACO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACO1, ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1, aconitase 1
External IDsOMIM: 100880; MGI: 87879; HomoloGene: 1657; GeneCards: ACO1; OMA:ACO1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278352
NM_002197
NM_001362840

NM_007386

RefSeq (protein)

NP_001265281
NP_002188
NP_001349769

NP_031412

Location (UCSC)Chr 9: 32.38 – 32.45 MbChr 4: 40.14 – 40.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aconitase 1, soluble is a protein that in humans is encoded by the ACO1 gene.[5]

Function

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The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122729Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028405Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Aconitase 1, soluble".
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.