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ATP2B3

From Wikipedia, the free encyclopedia
ATP2B3
Identifiers
AliasesATP2B3, CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1, ATPase plasma membrane Ca2+ transporting 3
External IDsOMIM: 300014; MGI: 1347353; HomoloGene: 123775; GeneCards: ATP2B3; OMA:ATP2B3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001001344
NM_021949
NM_001388360
NM_001388361
NM_001388362

NM_177236
NM_001310537

RefSeq (protein)

NP_001001344
NP_068768

n/a

Location (UCSC)Chr X: 153.52 – 153.58 MbChr X: 72.55 – 72.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plasma membrane calcium-transporting ATPase 3 (PMCA3) is an enzyme that in humans is encoded by the ATP2B3 gene.[5][6]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067842Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031376Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang MG, Yi H, Hilfiker H, Carafoli E, Strehler EE, McBride OW (Jun 1994). "Localization of two genes encoding plasma membrane Ca2+ ATPases isoforms 2 (ATP2B2) and 3 (ATP2B3) to human chromosomes 3p26→p25 and Xq28, respectively". Cytogenet Cell Genet. 67 (1): 41–5. doi:10.1159/000133794. PMID 8187550.
  6. ^ a b "Entrez Gene: ATP2B3 ATPase, Ca++ transporting, plasma membrane 3".
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Further reading

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