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BAMBI

From Wikipedia, the free encyclopedia
BAMBI
Identifiers
AliasesBAMBI, NMA, BMP and activin membrane-bound inhibitor, BMP and activin membrane bound inhibitor
External IDsOMIM: 604444; MGI: 1915260; HomoloGene: 8215; GeneCards: BAMBI; OMA:BAMBI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012342

NM_026505

RefSeq (protein)

NP_036474

NP_080781

Location (UCSC)Chr 10: 28.68 – 28.68 MbChr 18: 3.51 – 3.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.[5][6]

Function

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This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000095739Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024232Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)".
  6. ^ Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW, Bloemers HP (February 1996). "Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts". Int. J. Cancer. 65 (4): 460–5. doi:10.1002/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E. PMID 8621228.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.