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Dectaflur

From Wikipedia, the free encyclopedia
Dectaflur
Clinical data
Routes of
administration
Topical (gel, solution)
ATC code
  • none
Legal status
Legal status
Identifiers
  • 9-Octadeceylamine hydrofluoride
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.297.781 Edit this at Wikidata
Chemical and physical data
FormulaC18H38FN
Molar mass287.507 g·mol−1
3D model (JSmol)
  • [F-].C(=C/CCCCCCCC)\CCCCCCCC[NH3+]
  • InChI=1S/C18H37N.FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19;/h9-10H,2-8,11-19H2,1H3;1H/b10-9+;
  • Key:QGSCPWWHMSCFOV-RRABGKBLSA-N

Dectaflur (INN) is a fluoride-containing substance used for the prevention and treatment of dental caries, sensitive teeth, and the refluoridation of damaged tooth enamel, typically in combination with olaflur.[1]

Chemistry and mechanism of action

[edit]

Dectaflur consists of oleyl amine (the amine corresponding to oleyl alcohol) and hydrofluoric acid. Oleyl amine with its long lipophilic hydrocarbon chain has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the top layers of the enamel, reaching a depth of only a few nanometers. The precise mechanism of action is unknown.[2]

Side effects

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Like other fluorides, dectaflur is toxic when overdosed over an extended period of time. Especially in children, before the development of the permanent teeth, overdosage can lead to dental fluorosis.[3]

References

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  1. ^ Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Elmex Zahngel. ISBN 978-3-85200-196-8.
  2. ^ Müller F, Zeitz C, Mantz H, Ehses KH, Soldera F, Schmauch J, et al. (December 2010). "Elemental depth profiling of fluoridated hydroxyapatite: saving your dentition by the skin of your teeth?". Langmuir. 26 (24): 18750–9. doi:10.1021/la102325e. PMID 21090577.
  3. ^ Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL (February 2009). "Dental fluorosis: exposure, prevention and management". Medicina Oral, Patologia Oral y Cirugia Bucal. 14 (2): E103-7. PMID 19179949.