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EGOT (gene)

From Wikipedia, the free encyclopedia
EGOT
Identifiers
AliasesEGOT, EGO, NCRNA00190, eosinophil granule ontogeny transcript (non-protein coding), eosinophil granule ontogeny transcript
External IDsOMIM: 611662; GeneCards: EGOT; OMA:EGOT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)Chr 3: 4.75 – 4.75 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

EGOT, also known as Eosinophil Granule Ontogeny (EGO)† Transcript (non-protein coding),[3] is a human gene at 3p26.1 that produces a long noncoding RNA molecule. EGOT is nested within an intron of the inositol triphosphate receptor type 1 (ITPR1) gene. The EGOT transcript is expressed during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.[3] Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.[4]

†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000235947Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b Wagner LA, Christensen CJ, Dunn DM, et al. (June 2007). "EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression". Blood. 109 (12): 5191–5198. doi:10.1182/blood-2006-06-027987. PMC 1890841. PMID 17351112.
  4. ^ Rose D, Stadler PF (October 2011). "Molecular evolution of the non-coding eosinophil granule ontogeny transcript". Front Genet. 2: 69. doi:10.3389/fgene.2011.00069. PMC 3268622. PMID 22303364.
  5. ^ Wright, MW (Apr 9, 2014). "A short guide to long non-coding RNA gene nomenclature". Human Genomics. 8 (1): 7. doi:10.1186/1479-7364-8-7. PMC 4021045. PMID 24716852.