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ORM1

From Wikipedia, the free encyclopedia
ORM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesORM1, AGP-A, AGP1, HEL-S-153w, ORM, orosomucoid 1
External IDsOMIM: 138600; MGI: 97445; HomoloGene: 128040; GeneCards: ORM1; OMA:ORM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000607

NM_013623
NM_001379520
NM_001379521

RefSeq (protein)

NP_000598

n/a

Location (UCSC)Chr 9: 114.32 – 114.33 MbChr 4: 63.27 – 63.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.[5]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.[5]

Interactions

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ORM1 has been shown to interact with Plasminogen activator inhibitor-1.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000229314Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028359Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ORM1 orosomucoid 1".
  6. ^ Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. 276 (38). United States: 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606.

Further reading

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