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PDSS2

From Wikipedia, the free encyclopedia
PDSS2
Identifiers
AliasesPDSS2, C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1, prenyl (decaprenyl) diphosphate synthase, subunit 2, decaprenyl diphosphate synthase subunit 2, COQ1B
External IDsOMIM: 610564; MGI: 1918615; HomoloGene: 56885; GeneCards: PDSS2; OMA:PDSS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020381

NM_001168289
NM_027772

RefSeq (protein)

NP_065114

NP_001161761
NP_082048

Location (UCSC)Chr 6: 107.15 – 107.46 MbChr 10: 43.1 – 43.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.[5]

Function

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The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.[5]

Clinical significance

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It may be associated with Coenzyme Q10 deficiency.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164494Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038240Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: prenyl (decaprenyl) diphosphate synthase".
  6. ^ Online Mendelian Inheritance in Man (OMIM): 607426

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.