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TRIM33

From Wikipedia, the free encyclopedia
TRIM33
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
External IDsOMIM: 605769; MGI: 2137357; HomoloGene: 9296; GeneCards: TRIM33; OMA:TRIM33 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015906
NM_033020

NM_001079830
NM_053170

RefSeq (protein)

NP_056990
NP_148980

NP_001073299
NP_444400

Location (UCSC)Chr 1: 114.39 – 114.51 MbChr 3: 103.19 – 103.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.[5] [6]

TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.[7]

Structure

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The protein is a member of the tripartite motif family.[8] This motif includes three zinc-binding domains:

  • RING
  • B-box type 1 zinc finger
  • B-box type 2 zinc finger

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[7]

Interactions

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TRIM33 has been shown to interact with TRIM24.[9]

Role in cancer

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TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.[10] TRIM33 regulates also the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells. [11] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.[12]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197323Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033014Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "UniProt". www.uniprot.org. Retrieved 19 December 2022.
  6. ^ Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127. S2CID 45515641.
  7. ^ a b "Entrez Gene: TRIM33 tripartite motif-containing 33".
  8. ^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  9. ^ Peng H, Feldman I, Rauscher FJ (July 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
  10. ^ Aucagne R, Droin N, Paggetti J, Lagrange B, Largeot A, Hammann A, Bataille A, Martin L, Yan KP, Fenaux P, Losson R, Solary E, Bastie JN, Delva L (June 2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". The Journal of Clinical Investigation. 121 (6): 2361–70. doi:10.1172/JCI45213. PMC 3104753. PMID 21537084.
  11. ^ Quéré R, Saint-Paul L, Carmignac V, Martin RZ, Chrétien ML, Largeot A, Hammann A, Pais de Barros JP, Bastie JN, Delva L (July 2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 111 (29): 10592–7. Bibcode:2014PNAS..11110592Q. doi:10.1073/pnas.1405546111. PMC 4115559. PMID 25002492.
  12. ^ Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR (April 2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife. 4: e06377. doi:10.7554/eLife.06377. PMC 4409649. PMID 25919951.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.