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User:Mr. Ibrahem/Ozenoxacin

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Mr. Ibrahem/Ozenoxacin
Clinical data
Pronunciationoz en ox' a sin
Trade namesOzanex; Xepi
AHFS/Drugs.comMonograph
MedlinePlusa618010
License data
Routes of
administration		Topical
Drug classAntibiotic (quinolone)[1]
Legal status
Legal status
Identifiers
  • 1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Chemical and physical data
FormulaC21H21N3O3
Molar mass363.417 g·mol−1
3D model (JSmol)
  • O=C\3c1c(c(c(cc1)c2cc(c(nc2)NC)C)C)N(/C=C/3C(=O)O)C4CC4
  • InChI=1S/C21H21N3O3/c1-11-8-13(9-23-20(11)22-3)15-6-7-16-18(12(15)2)24(14-4-5-14)10-17(19(16)25)21(26)27/h6-10,14H,4-5H2,1-3H3,(H,22,23)(H,26,27)
  • Key:XPIJWUTXQAGSLK-UHFFFAOYSA-N

Ozenoxacin, sold under the brand names Ozanex and Xepi, is an antibiotic used to treat impetigo.[1] This includes impetigo due to methicillin-resistant S. aureus (MRSA).[3] It is applied to the skin as a cream.[3]

As little is absorbed through the skin; side effects are uncommon.[3] Side effects may include seborrheic dermatitis.[4] It is not expected to be harmful in pregnancy or breastfeeding.[1] It is a quinolone and works by blocking DNA gyrase A and topoisomerase IV.[1]

Ozenoxacin was approved for medical use in the United States and Canada in 2017.[1][5] In the United States a 30 gram tube of 1% cream costs about 340 USD as of 2021.[6] This amount in Canada costs about 53 CAD.[7]

References

[edit]
  1. ^ a b c d e f "DailyMed - XEPI- ozenoxacin cream". dailymed.nlm.nih.gov. Archived from the original on 11 November 2021. Retrieved 10 November 2021.
  2. ^ "Xepi- ozenoxacin cream". DailyMed. 30 January 2020. Archived from the original on 17 October 2020. Retrieved 13 October 2020.
  3. ^ a b c d Robertson, Dirk B.; Maibach, Howard I. (2020). "61. Dermatologic pharmacology". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. p. 1112. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-07.
  4. ^ "Ozenoxacin Monograph for Professionals". Drugs.com. Archived from the original on 15 October 2020. Retrieved 10 November 2021.
  5. ^ Canada, Health (30 June 2017). "Notice: Prescription Drug List (PDL): Multiple Additions [2017-06-23]". www.canada.ca. Archived from the original on 8 July 2021. Retrieved 10 November 2021.
  6. ^ "Xepi Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 November 2021.
  7. ^ "Pharmacoeconomic Review Report" (PDF). CADTH. Archived (PDF) from the original on 19 October 2019. Retrieved 10 November 2021.
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