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Utrophin

From Wikipedia, the free encyclopedia
UTRN
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesUTRN, DMDL, DRP, DRP1, utrophin
External IDsOMIM: 128240; MGI: 104631; HomoloGene: 21398; GeneCards: UTRN; OMA:UTRN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007124
NM_001375323

NM_011682

RefSeq (protein)

NP_009055
NP_001362252

n/a

Location (UCSC)Chr 6: 144.29 – 144.85 MbChr 10: 12.26 – 12.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Utrophin is a protein that in humans is encoded by the UTRN gene.[5][6] The name is a short form for ubiquitous dystrophin.

The protein encoded by this gene is a component of the cytoskeleton. Utrophin was found during research into Duchenne's muscular dystrophy, where boosting its production was found to prevent cellular damage from occurring.[7] The 900 kb gene for utrophin is found on the long arm of human chromosome 6. Utrophin was discovered due to its homology with dystrophin. It was found by screening a peptide containing the C-terminal domain of dystrophin against cDNA libraries. The homology varies over its full length from less than 30% in regions of the central rod structural domain to 85% (identity 73%) for the actin binding domain.

The tertiary structure of utrophin contains a C-terminus that consists of protein–protein interaction motifs that interact with dystroglycan, a central rod region consisting of a triple coiled-coil repeat, and an actin-binding N-terminus.

In normal muscle cells, utrophin is located at the neuromuscular synapse and myotendinous junctions. It is necessary for normal membrane maintenance, and for the clustering of the acetylcholine receptor. In adult humans, utrophin RNA is found ubiquitously, as the name implies, being abundant in the brain, kidney, liver, lung, muscle, spleen and stomach. In the human fetus during muscle differentiation, utrophin is found at the sarcolemma. It disappears when the fetus begins to express dystrophin.

Utrophin expression is dramatically increased in patients with Duchenne's muscular dystrophy (and female carriers), both in those muscle fibers lacking dystrophin and in rare, revertant fibers that express dystrophin.

No reports have yet associated mutation in the utrophin gene with disease, but it does not seem to play a critical role in development, since mice without utrophin develop normally.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152818Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019820Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nguyen TM, Le TT, Blake DJ, Davies KE, Morris GE (Dec 1992). "Utrophin, the autosomal homologue of dystrophin, is widely-expressed and membrane-associated in cultured cell lines". FEBS Lett. 313 (1): 19–22. doi:10.1016/0014-5793(92)81174-K. PMID 1426262. S2CID 22121696.
  6. ^ "Entrez Gene: UTRN utrophin".
  7. ^  This article incorporates text available under the CC BY 4.0 license. Betts, J Gordon; Desaix, Peter; Johnson, Eddie; Johnson, Jody E; Korol, Oksana; Kruse, Dean; Poe, Brandon; Wise, James; Womble, Mark D; Young, Kelly A (May 14, 2023). Anatomy & Physiology. Houston: OpenStax CNX. 10.3 Muscle Fiber Contraction and Relaxation. ISBN 978-1-947172-04-3.

Further reading

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