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YTHDC1

From Wikipedia, the free encyclopedia
YTHDC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesYTHDC1, YT521, YT521-B, YTH domain containing 1
External IDsOMIM: 617283; MGI: 2443713; HomoloGene: 15796; GeneCards: YTHDC1; OMA:YTHDC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001031732
NM_133370
NM_001330698

NM_177680
NM_001347375
NM_001347376
NM_001359907
NM_001359908

RefSeq (protein)

NP_001026902
NP_001317627
NP_588611

NP_001334304
NP_001334305
NP_808348
NP_001346836
NP_001346837

Location (UCSC)Chr 4: 68.31 – 68.35 MbChr 5: 86.95 – 86.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.[5][6][7] YTHDC1 is a nuclear protein involved in splice site selection that localises to YT bodies; dynamic subnuclear compartments, which first appear at the beginning of S-phase in the cell cycle and disperse during mitosis.[8]

Interactions

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YTHDC1 has been shown to interact with:

Role in disease

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Alternative splicing is altered in a number of diseases and is particularly relevant to cancer.

Cancer

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YTHDC1 has been shown to splice mRNA transcripts which have oncological importance, regulating tumour functions such as hypoxia associated vascular endothelial growth factor (VEGF), DNA damage associated breast cancer 1 (BRCA1) and hormonal growth driver; the progesterone receptor (PGR).[12][13]

In prostate cancer, YTHDC1 has also been shown to interact with the protein metadherin, encoded by the oncogene MTDH acting to influence alternative splicing of tumour-related genes such as CD44.[11][14]

See also

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N6-Methyladenosine

References

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  1. ^ a b c ENSG00000083896 GRCh38: Ensembl release 89: ENSG00000275272, ENSG00000083896Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035851Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci. 27 (10): 495–7. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.
  6. ^ a b Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Mol Biol Cell. 10 (11): 3909–26. doi:10.1091/mbc.10.11.3909. PMC 25688. PMID 10564280.
  7. ^ "Entrez Gene: YTHDC1 YTH domain containing 1".
  8. ^ Nayler, O.; Hartmann, A. M.; Stamm, S. (2000-09-04). "The ER repeat protein YT521-B localizes to a novel subnuclear compartment". The Journal of Cell Biology. 150 (5): 949–962. doi:10.1083/jcb.150.5.949. ISSN 0021-9525. PMC 2175241. PMID 10973987.
  9. ^ a b Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
  10. ^ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.
  11. ^ a b Luxton, Hayley J.; Simpson, Benjamin S.; Mills, Ian G.; Brindle, Nicola R.; Ahmed, Zeba; Stavrinides, Vasilis; Heavey, Susan; Stamm, Stefan; Whitaker, Hayley C. (2019-08-23). "The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing". Cancers. 11 (9): 1233. doi:10.3390/cancers11091233. ISSN 2072-6694. PMC 6770463. PMID 31450747.
  12. ^ Hirschfeld, Marc; Zhang, Bo; Jaeger, Markus; Stamm, Stefan; Erbes, Thalia; Mayer, Sebastian; Tong, Xiaowen; Stickeler, Elmar (November 2014). "Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression". Molecular Carcinogenesis. 53 (11): 883–892. doi:10.1002/mc.22045. ISSN 1098-2744. PMID 23765422. S2CID 35669580.
  13. ^ Zhang, Bo; Shao, Xiaowen; Zhou, Jianhong; Qiu, Jin; Wu, Yi; Cheng, Jiajing (2015-08-21). "YT521 promotes metastases of endometrial cancer by differential splicing of vascular endothelial growth factor A". Tumor Biology. 37 (12): 15543–15549. doi:10.1007/s13277-015-3908-y. ISSN 1423-0380. PMID 26289848. S2CID 11257001.
  14. ^ Yoo, Byoung Kwon; Emdad, Luni; Su, Zao-zhong; Villanueva, Augusto; Chiang, Derek Y.; Mukhopadhyay, Nitai D.; Mills, Alan Scott; Waxman, Samuel; Fisher, Robert A.; Llovet, Josep M.; Fisher, Paul B. (March 2009). "Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression". The Journal of Clinical Investigation. 119 (3): 465–477. doi:10.1172/JCI36460. ISSN 1558-8238. PMC 2648696. PMID 19221438.

Further reading

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