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PCCG-4

С Википедије, слободне енциклопедије
PCCG-4
IUPAC ime
(2S,1'S,2'S,3'R)-2-(2'karboksi-3'-fenilciklopropil)glicin
Identifikatori
ATC kodnone
PubChemCID 5311344
ChemSpider4470843 ДаY
ChEMBLCHEMBL39573 ДаY
Hemijski podaci
FormulaC12H13NO4
Molarna masa235,235 g/mol
  • C1=CC=C(C=C1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N
  • InChI=1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m1/s1 ДаY
  • Key:IFLWVSHRWAIVQF-KATARQTJSA-N ДаY

PCCG-4 je istraživački lek koji deluje kao selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), sa neznatnom selektivnošću za mGluR2. Ona nije dovoljna za razlikovanje mGluR2 i mGluR3 responsa. PCCG-4 se koristi u istraživanjima funkcije grupe II metabotropnih glutamatnih receptora.[1][2][3][4][5]

  1. ^ Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (1996). „Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist”. Journal of Medicinal Chemistry. 39 (11): 2259—69. PMID 8667369. doi:10.1021/jm960059+. 
  2. ^ Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (1996). „(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors”. Molecular Pharmacology. 50 (1): 6—9. PMID 8700119. 
  3. ^ Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (1997). „Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist”. The European Journal of Neuroscience. 9 (7): 1350—5. PMID 9240392. 
  4. ^ Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (1999). „Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes”. Glia. 27 (3): 275—81. PMID 10457374. 
  5. ^ Vetter P, Garthwaite J, Batchelor AM (1999). „Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors”. Neuropharmacology. 38 (6): 805—15. PMID 10465684. doi:10.1016/S0028-3908(99)00003-9. 

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