Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes (Q59349684)

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English	Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes	article

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Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes (English)

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5 May 2020

Celia C LaBranche

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5 May 2020

Gabriel Ozorowski

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Rogier W Sanders

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Per Johan Klasse

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Marit J. van Gils

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Christopher A. Cottrell

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Ian Andrew Wilson

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David C. Montefiori

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Thomas J Ketas

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Pavel Pugach

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Anna Schorcht

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Gemma E Seabright

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Rajesh P Ringe

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5 May 2020

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Sonu Kumar

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28 November 2018

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Journal of Virology

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5 May 2020

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5 May 2020

Epitopes on protein antigens: misconceptions and realities.

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Intrinsic and extrinsic factors in protein antigenic structure

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Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.

1 reference

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Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization

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12 December 2020

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UCSF Chimera--a visualization system for exploratory research and analysis

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https://pubmed.ncbi.nlm.nih.gov/30487280

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based on heuristic

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Modeling how many envelope glycoprotein trimers per virion participate in human immunodeficiency virus infectivity and its neutralization by antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies

1 reference

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MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1.

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12 December 2020

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How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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Kinetic mechanism for HIV-1 neutralization by antibody 2G12 entails reversible glycan binding that slows cell entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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The molecular basis of HIV entry

1 reference

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12 December 2020

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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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Antibodies in HIV-1 vaccine development and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

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Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

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Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

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Targeting B-cell germlines and focusing affinity maturation: the next hurdles in HIV-1-vaccine development?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

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Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

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Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Progress toward active or passive HIV-1 vaccination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

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based on heuristic

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Germline-targeting immunogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

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based on heuristic

inferred from PubMed ID database lookup

Native-like Env trimers as a platform for HIV-1 vaccine design

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HIV-1 envelope glycoprotein structure: nailing down a moving target

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global site-specific N-glycosylation analysis of HIV envelope glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neutralization tiers of HIV-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity in rabbits of SOSIP trimers from clades A, B and C, given individually, sequentially or in combinations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and Immune Recognition of the HIV Glycan Shield.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30487280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.01656-18

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30487280%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30487280%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30487280%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

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