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CCL13

S Wikipedije, slobodne enciklopedije
CCL13
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2RA4

Identifikatori
AliasiCCL13
Vanjski ID-jeviOMIM: 601391 MGI: 98259 HomoloGene: 2241 GeneCards: CCL13
Lokacija gena (čovjek)
Hromosom 17 (čovjek)
Hrom.Hromosom 17 (čovjek)[1]
Hromosom 17 (čovjek)
Genomska lokacija za CCL13
Genomska lokacija za CCL13
Bend17q12Početak34,356,480 bp[1]
Kraj34,358,610 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za CCL13
Genomska lokacija za CCL13
Bend11 C|11 49.82 cMPočetak82,035,571 bp[2]
Kraj82,037,453 bp[2]
Ontologija gena
Molekularna funkcija cytokine activity
chemokine activity
CCR chemokine receptor binding
signaling receptor binding
GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta extracellular region
Vanćelijsko
Biološki proces monocyte chemotaxis
cell-cell signaling
eosinophil chemotaxis
Hemotaksija
GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
cytoskeleton organization
GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor
positive regulation of ERK1 and ERK2 cascade
regulation of cell shape
GO:0072468 Transdukcija signala
inflammatory response
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular calcium ion homeostasis
neutrophil chemotaxis
lymphocyte chemotaxis
chemokine-mediated signaling pathway
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
cell chemotaxis
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_005408

NM_011333

RefSeq (bjelančevina)

NP_005399

NP_035463

Lokacija (UCSC)Chr 17: 34.36 – 34.36 MbChr 11: 82.04 – 82.04 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš
Hemokinski (C-C motivni) ligand 13
Identifikatori
SimbolCCL13
Alt. simboliSCYA13, MCP-4, NCC-1, SCYL1, CKb10
NCBI gen6357
HGNC10611
OMIM601391
RefSeqNM_005408
UniProtQ99616
Ostali podaci
LokusHrom. 17 q11.2
Pretraga za
StruktureSwiss-model
DomeneInterPro

Hemokinski (C-C motivni) ligand 13 (CCL13) jest mali citokin koji pripada porodici CC hemokina. Njegov gen nalazi se na ljudskom hromosomu 17 unutar velike grupe drugih CC-hemokina.[5][6] CCL13 inducira hemotaksiju u monocitima, eozinofilima, T-limfocitima i bazofilima, vezanjem G-proteina na ćelijskoj površini, preko hemokinskih receptora, kao što su CCR2, CCR3 i CCR5.[7] Aktivnost ovog hemokina uključena je u alergijske reakcije kao što je astma.[8] CCL13 mogu inducirati upalni citokini interleukin-1 i TNF-α.

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 98 aminokiselina, a molekulska težina 10.986 Da.[9]

1020304050
MKVSAVLLCLLLMTAAFNPQGLAQPDALNVPSTCCFTFSSKKISLQRLKS
YVITTSRCPQKAVIFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT
Simboli

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181374 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035385 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626
  6. ^ Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.
  7. ^ Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
  8. ^ Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.
  9. ^ "UniProt, Q99616". Pristupljeno 28. 6. 2021.