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ADAM11

From Wikipedia, the free encyclopedia
ADAM11
Identifiers
AliasesADAM11, MDC, ADAM metallopeptidase domain 11
External IDsOMIM: 155120; MGI: 1098667; HomoloGene: 7614; GeneCards: ADAM11; OMA:ADAM11 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002390
NM_001318933

NM_001110778
NM_009613

RefSeq (protein)

NP_001305862
NP_002381

NP_001104248
NP_033743

Location (UCSC)Chr 17: 44.76 – 44.78 MbChr 11: 102.65 – 102.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.[5][6]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073670Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020926Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040. S2CID 11770397.
  6. ^ a b "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11".

Further reading

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