Jump to content

ADAM8

From Wikipedia, the free encyclopedia

ADAM8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADAM8, CD156, CD156a, MS2, ADAM metallopeptidase domain 8
External IDsOMIM: 602267; MGI: 107825; HomoloGene: 74384; GeneCards: ADAM8; OMA:ADAM8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001109
NM_001164489
NM_001164490

NM_001291066
NM_007403

RefSeq (protein)

NP_001100
NP_001157961
NP_001157962

NP_001277995
NP_031429

Location (UCSC)Chr 10: 133.26 – 133.28 MbChr 7: 139.56 – 139.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.[5][6]

Function

[edit]

This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.[6]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151651Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025473Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (April 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
  6. ^ a b "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

Further reading

[edit]
[edit]
  • The MEROPS online database for peptidases and their inhibitors: M12.208
  • ADAM8 human gene location in the UCSC Genome Browser.
  • ADAM8 human gene details in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.