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CEACAM3

From Wikipedia, the free encyclopedia
CEACAM3
Identifiers
AliasesCEACAM3, CD66D, CEA, CGM1, W264, W282, carcinoembryonic antigen related cell adhesion molecule 3, CEA cell adhesion molecule 3
External IDsOMIM: 609142; HomoloGene: 130497; GeneCards: CEACAM3; OMA:CEACAM3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277163
NM_001815

n/a

RefSeq (protein)

NP_001264092
NP_001806

n/a

Location (UCSC)Chr 19: 41.8 – 41.81 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..[3]

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

Use

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CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.[4]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170956Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3".
  4. ^ CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.