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Galanin receptor 1

From Wikipedia, the free encyclopedia

GALR1
Identifiers
AliasesGALR1, GALNR, GALNR1, Galanin receptor 1
External IDsOMIM: 600377; MGI: 1096364; HomoloGene: 74396; GeneCards: GALR1; OMA:GALR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001480

NM_008082

RefSeq (protein)

NP_001471

NP_032108

Location (UCSC)Chr 18: 77.25 – 77.28 MbChr 18: 82.41 – 82.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.[5]

Function

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The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166573Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024553Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GALR1 galanin receptor 1".

Further reading

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  • "Galanin Receptors: GAL1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.