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Neuromedin B receptor

From Wikipedia, the free encyclopedia
NMBR
Identifiers
AliasesNMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDsOMIM: 162341; MGI: 1100525; HomoloGene: 20560; GeneCards: NMBR; OMA:NMBR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002511
NM_001324307
NM_001324308

NM_008703

RefSeq (protein)

NP_001311236
NP_001311237
NP_002502

NP_032729

Location (UCSC)Chr 6: 142.06 – 142.15 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The neuromedin B receptor (NMBR), now known as BB1 [4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[5] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135577Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-10-04. Retrieved 2007-10-25.
  5. ^ Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
  6. ^ "Entrez Gene: NMBR neuromedin B receptor".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.