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DLX2

From Wikipedia, the free encyclopedia
DLX2
Identifiers
AliasesDLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
External IDsOMIM: 126255; MGI: 94902; HomoloGene: 3244; GeneCards: DLX2; OMA:DLX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004405

NM_010054

RefSeq (protein)

NP_004396
NP_004396.1

NP_034184

Location (UCSC)Chr 2: 172.1 – 172.1 MbChr 2: 71.37 – 71.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.[5][6]

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.[6]

Interactions

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DLX2 has been shown to interact with DLX5,[7] MSX1[7] and Msh homeobox 2.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115844Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023391Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics. 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641.
  6. ^ a b "Entrez Gene: DLX2 distal-less homeobox 2".
  7. ^ a b c Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. 17 (5). UNITED STATES: 2920–32. doi:10.1128/mcb.17.5.2920. ISSN 0270-7306. PMC 232144. PMID 9111364.

Further reading

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