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TEAD3

From Wikipedia, the free encyclopedia
TEAD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTEAD3, DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, TEF5, TEA domain transcription factor 3
External IDsOMIM: 603170; MGI: 109241; HomoloGene: 81821; GeneCards: TEAD3; OMA:TEAD3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003214
NM_001395214

NM_001098226
NM_001204156
NM_011566

RefSeq (protein)

NP_003205

NP_001091696
NP_001191085
NP_035696

Location (UCSC)Chr 6: 35.47 – 35.5 MbChr 17: 28.55 – 28.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional enhancer factor TEF-5 is a protein that in humans is encoded by the TEAD3 gene.[5][6][7]

Function

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This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. Transcriptional coregulators, such as WWTR1 (TAZ) bind to these transcription factors. TEAD3 is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. It is expressed in nervous system and muscle in fish embryos.[9] Translation of this protein is initiated at a non-AUG (AUA) start codon.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007866Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002249Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Jan 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics. 55 (1): 127–9. doi:10.1006/geno.1998.5628. hdl:2268/13836. PMID 9889009.
  6. ^ Jacquemin P, Martial JA, Davidson I (May 1997). "Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer". The Journal of Biological Chemistry. 272 (20): 12928–37. doi:10.1074/jbc.272.20.12928. PMID 9148898.
  7. ^ a b "Entrez Gene: TEAD3 TEA domain family member 3".
  8. ^ Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell. 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. S2CID 2819591.
  9. ^ Mann CJ, Osborn DP, Hughes SM (Oct 2007). "Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord". Gene Expression Patterns. 7 (8): 827–36. doi:10.1016/j.modgep.2007.08.001. PMC 3360971. PMID 17916448.

Further reading

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