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CAMK2D

From Wikipedia, the free encyclopedia
CAMK2D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCAMK2D, CAMKD, calcium/calmodulin dependent protein kinase II delta
External IDsOMIM: 607708; MGI: 1341265; HomoloGene: 55561; GeneCards: CAMK2D; OMA:CAMK2D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 4: 113.42 – 113.76 MbChr 3: 126.39 – 126.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.[5]

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145349Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053819Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta".

Further reading

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