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ZAK

From Wikipedia, the free encyclopedia
MAP3K20
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAP3K20, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK, mitogen-activated protein kinase kinase kinase 20, MLTKalpha, MLTKbeta, CNM6
External IDsOMIM: 609479; MGI: 2443258; HomoloGene: 32331; GeneCards: MAP3K20; OMA:MAP3K20 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016653
NM_133646

NM_001164791
NM_023057
NM_178084

RefSeq (protein)

NP_057737
NP_598407

NP_001158263
NP_075544
NP_835185

Location (UCSC)Chr 2: 173.08 – 173.27 MbChr 2: 72.12 – 72.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.[5]

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5] [6]

Interactions

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ZAK has been shown to interact with ZNF33A.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091436Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004085Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ZAK sterile alpha motif and leucine zipper containing kinase AZK".
  6. ^ Liu, Te-Chung; Huang, Chang-Jen; Chu, Yu-Chuan; Wei, Chih-Chang; Chou, Chun-Chieh; Chou, Ming-Yung; Chou, Chen-Kung; Yang, Jaw-Ji (11 August 2000). "Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif". Biochemical and Biophysical Research Communications. 274 (3): 811–816. doi:10.1006/bbrc.2000.3236. PMID 10924358.
  7. ^ Yang, Jaw-Ji (Jan 2003). "A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle". Biochem. Biophys. Res. Commun. 301 (1): 71–7. doi:10.1016/S0006-291X(02)02980-7. ISSN 0006-291X. PMID 12535642.
  • Lee, Jin-Sun (28 February 2018). "Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK". The Chinese Journal of Physiology. 61 (1): 25–34. doi:10.4077/CJP.2018.BAG528. PMID 29374956.

Further reading

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