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FASTK

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FASTK
Identifiers
AliasesFASTK, Fastk, 0610011K02Rik, 610011K02Rik, FAST, Fas activated serine/threonine kinase
External IDsOMIM: 606965; MGI: 1913837; HomoloGene: 4884; GeneCards: FASTK; OMA:FASTK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258461
NM_006712
NM_033015

NM_023229

RefSeq (protein)

NP_001245390
NP_006703
NP_148936

n/a

Location (UCSC)Chr 7: 151.08 – 151.08 MbChr 5: 24.64 – 24.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.[5][6][7]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates the apoptosis-promoting nuclear RNA-binding protein TIA1. The encoded protein is a strong inducer of lymphocyte apoptosis.

Two transcript variants encoding different isoforms have been found for this gene. The longer one is located in the cell nucleus and cytoplasm, and the shorter one is 34 amino acids at the N-terminus, which is transported to the mitochondrion.[8]

The mitochondrial FASTK isoform localizes in the mitochondrial granules, where it interacts with the GRSF1 protein and binds to mt-mRNA ND6, the template of the only protein encoded on the light strand of the mitochondrial genome. In the case of FASTK deletion, it was observed loss of ND6 mt-mRNA and a 50-60% decrease in the activity of complex I of the respiratory chain. However, overexpression of this protein resulted in the stabilization of ND6 mt-mRNA [8][9]

Other variants exist, but their full-length natures have not yet been determined.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164896Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028959Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (September 1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis". The Journal of Experimental Medicine. 182 (3): 865–874. doi:10.1084/jem.182.3.865. PMC 2192163. PMID 7544399.
  6. ^ Li W, Simarro M, Kedersha N, Anderson P (December 2004). "FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression". Molecular and Cellular Biology. 24 (24): 10718–10732. doi:10.1128/MCB.24.24.10718-10732.2004. PMC 533970. PMID 15572676.
  7. ^ a b "Entrez Gene: FASTK Fas-activated serine/threonine kinase".
  8. ^ a b Jourdain AA, Popow J, de la Fuente MA, Martinou JC, Anderson P, Simarro M (November 2017). "The FASTK family of proteins: emerging regulators of mitochondrial RNA biology". Nucleic Acids Research. 45 (19): 10941–10947. doi:10.1093/nar/gkx772. PMC 5737537. PMID 29036396.
  9. ^ Jourdain AA, Koppen M, Rodley CD, Maundrell K, Gueguen N, Reynier P, et al. (February 2015). "A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function". Cell Reports. 10 (7): 1110–1121. doi:10.1016/j.celrep.2015.01.063. hdl:10261/157664. PMID 25704814.

Further reading

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